A mordern fantasy type vibe. Where there can be mysticism or psychics involved, and traditional weapons used. A blessed family Spear, or a good ol shotgun are both viable options.

The Secret World, Or The Dresden Files might help with some.
In that a bunch of different approaches can be applied to the same problem depending.

Although, while a mysticism approach may exist. 
Probably not going to go off the same vibes of the "hunters" having trouble directly encountering the supernatural. Not that they'll always come out on top. Just that they'll have means or train into directly combating them in a physical sense once they cornered / encountered the entity.