Red comic sans? Ouch. A sentence is OK, but a whole post like that ... my poor eyes.
I am personally on the opinion that text should look as uniform as possible, with as little formatting as possible aside of the words that need stressing being bolded et cetera... I frequently enough find miself reading posts diagonally (or not reading them at all) because of painful colors, wonky fonts and/or other bizarre formatting as it is. (Centered alignment for anything but poems and titles? Please don't do that.)
On the technical side, I figure it would be easy enough to arrange, given the software is malleable enough.