So for this I'm thinking of a Sunshine or Moon style roleplay. Definitively sci-fi, but also has good character development (and un-development, I guess). Very much a sci-fi roleplay based on the psychological effects of the mission.
As a basic story right now, I'm thinking of a crew on a spaceship sent out into the abyss of space to never see Earth again; their only remaining mission in life is to find and document anything of interest. But 6 years into the mission, something has changed. Sure, the dynamic was going to evolve naturally with everyone only ever seeing their crew-mates for the rest of their loves, but something is amiss...
No aliens. No Star Wars or Mass Effect. No plasma rifles.
If you want to know more, please get in contact with me through here or PM me or whatever. Suggestions and ideas are welcome.
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Also, know your shit. Make up sciencey sounding things if it helps you, but have some sort of understanding of physics and space travel etc.