Well, as far as sadness goes, yes.
But just judging by the impact left on the player after the ending? I gotta go with Red Dead Redemption.
I love Red Dead Redemption, and it's one of the the best voice acted games of our generation, but the ending there didn't really hit a chord with me. I think a part of it was it was spoiled for me a while back, but even so, it just played out like normal for me, which I wish it didn't.
A special thanks to MissCapnCrunch for the sig!
And another special thanks to Tick for the avatar!
You guys rock my Casbah!