Ok so hopefully you guys have heard of American Horror Story Asylum, if not it's about an asylum in the 1906's that got shut down in the 1970's.
It is 2014 and Briarcliff reopens its doors after a famous doctor renovates it. It seems completely harmless now with darkness looming around. How could it with the bright new paint and technology? But here's the thing it only seems harmless on the surface and because it's new no one suspects anything. But the reason it is reopening is because the doctor wants to use the patients as guinea pigs for his new experiments to create super humans and bio-weapons for the Government, who happens to be funding everything. And what better way to test it on crazies? because if they are cured they look like geniuses, if they die no one will notice, after all they've been abandoned there as it is.
That's the rough edges that can be smoothed out as people show interest. The basic plot is there is a handful of people that are first to enter Briarcliff as it reopens, they are completely oblivious to what they are about to endure, and slowly they start to realize and plan an escape. again rough edge plot that can be smoothed out as people show interest.