The cannon fires 120mm explosive bolts with a max range of 50km. And the explosion is enough to take out 1/3rd of a space station. Shooting him in the butthole won't even be necessary. He'll be nothing but hydrogen particles.

Thalos only ever killed someone like that once back at the Reach. A Solan Corp intelligence agent who was chillin' in a meeting room at one of Solan's administration stations.