[quote=Yog Sothoth]
seriously One Above All is God and has no weaknesses and is limitless, if Tengen Toppa Gurren Lagann can be defeated then he losses otherwise its a stand still for the rest eternity.
[/quote]

But you seem to forget the very theme of Gurren Lagann: "Do the impossible... See the invisible... Touch the untouchable... Break the unbreakable..." One Above All may be God, but that just makes him the most fitting kind prey. The Anti-Spiral tried phasing them out of reality, but Gurren Lagann literally broke the laws of the omniverse and came back on sheer willpower. Gurren Lagann embodies the idea of surpassing the limits imposed on us by apparent reality. One-Above-All seems content with omnipotence, so he has nowhere to go, and thus he would lose. He may be God, but Gurren Lagann is a God killer.