I'd say the only thing to really piss off Scalpel would be to harm Honey or for him to figure out you betrayed him, the former is actually an undercurrent to the plot as he has been systematically hunting down and murdering the Earthborn involved in her mutilation over the years. Either would basically involve him going out of his way to cause the person as much pain as possible, and killing Honey would basically result in him losing the last of his ethical restraints and sanity.

Also you said "friends and family" in the RP, so I presumed some relatives are dead at least.