I've played some Apocalypse World hacks with some people from here over Skype and [url=http://roll20.net]. It works just fine. Of course, in my eyes, AW really shines when you're not dependent on maps and figures and whatnot. It's definitely a different experience from playing around an actual table, but it's still a lot of fun.

Depending on the details (which game, frequency of sessions etc.) I'd totally be up for playing!