As someone inquired earlier, I believe a type of "pre-mutant" or set of abilities that may exist with non-manipulated genes might fit into the RP, and there's plenty of room to make these natural mutations and possibly genetic capabilities more like magic. You could actually set aside, using this logic, isolated genes for abilities associated with more cultural aspects, such as chi or other life energies, especially for isolated places of worship such as monks. That's a single example of many. If you want a dose of the supernatural and metaphysical, simply implement a character with genes and abilities the genetics at the time can't understand or replicate, and I'll likely allow some lee way. I'm more than happy to delve into adding an element of "metaphysical" energy, much like chi, mana, chakra, etc. that also works in terms of physics to give the roleplay and equalyl scientific and fantastical element.

Note: Anyone that wants to PM me anything is more than welcome to.