What Bee said pretty much. We'd be fucked if we pissed a single faction off, nevermind that our very nature would cause pretty much everyone to target us automatically. I'm not big on 40k powerwank but our party'd be screwed unless we like, stuck to a single planet without involving the rest of the universe and maybe secured an alliance, however flimsy, with a faction to ensure that we don't get attacked by everyone at once.

As for universes, pretty much anything is fine. I'd dig doing less obvious picks, though. Like, I don't have a problem with Skyrim or Dark Souls (Hyrule's kinda meh but I don't dislike it) but going somewhere less familiar would be cool IMO. Though since Idon't have any particular suggestions and I'm not really up for GMing anything I can't really complain about world picks now can I?