Having powers (telepathy/telekinesis etc) might fit if the character we play as is demonic/angelic or a witch/warlock. The only reason Sam had powers was because his blood had been tainted by the Yellow-eyed Demon and he lost the powers shortly after the events of season 2.
Also our GM has said this is going to be an original story so I dont know what he/she has planned in terms of what characters are available and if they are able to harness powers other than spells or hexes.

EDIT: Never read the Monster Hunter books (only ever heard of a Monster Hunter game)