I created the universe, but I didn't create a plot.  I'll post a few ideas, and if anyone else has an idea, feel free to post it.  I'll pick one after we discuss them.

1) Help rebuild and defend a small settlement.
2) Help my character gather what he needs to repair an old ship he found in a Rad-zone so that we can leave the planet.
3) Massive criminal plot to loot and enslave a series of villages.  We have to stop it,maybe for moral reasons, maybe for the reward the towns in the area put together.
4) Mission-of-the-week style.
5) We're Bounty hunters.
6) We're salvagers, going into dangerous areas and recovering tech few else will.