[@Kira]I seen that you listed Yuri and Yaoi under your interests, but I haven't had that much experience with them xD Anyways, if you want to do a MxF pairing, then here are the ideas I found interesting. 


Therapist/Doctor x Mental Patient*

Rival x Rival

Deity/Spirit* x Human

Criminal x Detective*

A Supernatural Creature (werewolf, humanized poltergeist, etc) x Human