The being tied up thing I got yeah. 

So yes, the rules of the toons can be stretched into resisting almost anything. 

By that logic, yes technically she should resist the effects of the Kolon grenades. Despite it being silly and somewhat tryhard-ish because of the comedy relief side of the thing, I can only agree that she is very well able to do this. 

Though I do have one question. What would happen if she were to enter a cartoon universe? Let's say Cyanide & Happiness. Would she be bound to the toon rules in that universe? Or is she the omnipotent God of toons? I guess you could also define what qualifies as a 'toon world' though.