Alright, well what about

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[img]http://img12.deviantart.net/ae34/i/2015/204/d/3/the_thing_by_disse86-d92kf4l.jpg[/img]
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Maybe someone was mutated by high levels of radiation and turned into a horrid monster that is terrorizing any travelers, but it only comes out at night. Last known supposed sighting was by a small roadside motel a few miles away? That'll allow for some goofy shit to happen, get to know each other, us having to track it down, etc. Maybe we have to find the source of the radiation to prevent other people from turning into things as well? Thoughts?