[quote=@SilverFallen]
[@Letter Bee] Can you explain what you mean by major NPCs? 
[/quote]

Ah, you make an NPC, give them a short summary of occupation and backstory - not as long as a regular PC - as well as a picture and SPECIAL stats. However, they have no skills or perks, meaning that while formidable opponents, they are not as good as a PC in a straight fight.

The purpose of the Major NPCs is to create characters that would fill up the world and interact with each other, and won't die as easily as mooks, thus meaning that they cannot be ignored.

Also, if you can justify it in your backstory, you can control some mooks/minions as well, aka minor NPCs.