[@Archmage MC]

Moana
Pocahontas
Mulan
Elsa
Emma from Once Upon a Time
Black Widow
Most of the DC/Marvel superheroines, with a few exceptions
Ray from Star wars 7
Jyn from Rogue One
Daenerys Targaryen
Cercei Lanister

I could keep going, but you get the point. There's no shortage of strong straight female leads. I can't list gay males, but thats because a lot of the 'mainstream' games I play are open world RPG games were being gay straight, both, or neither is a choice the player can decide, so thats a bit of a grey area.