[@thewizardguy], I did say in the beginning this was going to be about the people, not the powers. Guilt has set herself up in opposition to the High. You've said as much several times. She's pressing against the boundaries of the City. What else is supposed to happen but the enforcers of those boundaries start pushing back?

Guilt is, by her own admission, a weapon designed to kill Epics. She has set herself the goal of killing the High, or at least bringing them down to normal. She's declaring herself a player in a game she doesn't even fully comprehend. Island isn't being adversarial. He's trying to be nice. So was the Clairvoyant. They are, by all judgement, gods. And you thumbed your nose at the nicest of them.

Guilt's arc, as I see it, is her either healing from the experiments inflicted on her as a child, like River Tam from Firefly, or revelling in the monster they made her to be, until her powers become too strong for her to control. I would go with a normal person trying to redeem her, but I've had very little time with Guilt being anything other than a vengeful black hole. Did I pick up the wrong plotline for you?