All good responses. I've always found it funny that people seem to think that nukes in space are still as nasty as they are on planetside. The thing is, in a vaccum there's little to nothing to compress, so no compression wave really. What is, happens to be significantly reduced. Thermal shock is also greatly reduced as there's not a lot of convective or conductive heat, and most ships are well shielded against heat anyway. Most of the radiation would be shielded out too, but the EM pulse would be nasty for computers. Still you don't want one going off close. 

Great example is the newer Battlestar Galactica series. The Galactica had at least one nuke go off in it's face, and really wasn't too bad for the wear. EM shielding/hardening can rule out the rest of the significant effects of a nuke. 

Your answers make me happy, and yeah, I agree that dealing with Delta V and orbital mechanics and the like might be more sciency and more of a pain in the neck than most players want to deal with. I just wanted to see where you had in mind on the scale of hard science vs science fantasy you wanted things. I like where they are. XD