In the aftermath of Tyrael's daring act of destroying the Worldstone, a cataclysmic event ripples across the world of Sanctuary, leaving a void in its wake. As time passes, the absence of the Worldstone begins to take its toll on the delicate balance of the realm. The forces that once held the world together now unravel, causing decay and chaos to spread throughout Sanctuary.

It is during this tumultuous period that individuals find themselves born anew or infected by a mysterious force known as the Shardinum. The Shardborn are individuals who bear a unique connection to the shattered remnants of the Worldstone. This link manifests in them as latent power and extraordinary abilities, granting them an edge in the battle against the encroaching darkness.

Guided by the ancient wisdom of the Horadric Elder Deckard Cain, the Shardborn discover the true nature of their existence. Cain unveils an ominous prophecy that echoes through the annals of history, speaking of the inevitable collapse of Sanctuary without a divine artifact akin to the Worldstone to uphold its foundations.

Word of this dire revelation spreads like wildfire, reaching the ears of those who still cling to hope. Adventurers, both experienced and novice, both good and evil, begin to gather, driven by a common purpose. They understand that the fate of Sanctuary lies in their hands. United by their shared burden as Shardborn, they set out on a perilous quest to find a solution to this impending catastrophe.

Their journey takes them to forgotten lands, ancient ruins, and hidden enclaves, where they encounter a myriad of challenges. Along the way, they confront demonic hordes, ancient evils seeking to exploit the power of the shattered Worldstone, enigmatic cults that worship the chaos consuming Sanctuary, and much more. The adventurers must overcome these trials, not only to save themselves but also to safeguard the very existence of Sanctuary.