I wouldn't regret it, and it really wouldn't change the way I play him/her all that much. He'd go from big and burly to big and slim. Would win less arm wrestling matches, but overall it wouldn't change much.

As for the Inquisition, I think it would be fun to have it break up at some point and break off into little splinter groups, most of which are simply anti-mage warbands that focus on killing any mages they can find, with only one or maybe two being like the original Inquisition with "chivalry" and "for the good of mankind" in their anti-mage stuff.