So here's what I've come up with:
You want to want to have only one "Version" selected. They are nearly identical. But you should rotate through them for slight variation.
Always Include:
-The First Expansion
-The Second Expansion
-The Third Expansion
-The Fourth Expansion
-The Box Expansion
-PAX East 2013 Pack "A"
-Ridiculously Stupid
-Anime
-Mr. Man Collection
-Antisocial Injustice
Good, but should be cycled out:
-Canada
-2012 Holiday Pack
-Vidya
Considerable:
-Admin's Picks (repeats doe)
-Very Serious (meh)
-RPAnons (a bit too many references, but has semi-relevant cards relating to forums like this)
-Anime Expansion #1 (Anime already has loads of cards)
And you really should only go Furry -OR- Brony every round. Both is too much. Use Cards Against Equinity and not FiMFiction.net for pony.
Most of the other packs are filled with shitty references that wouldn't be funny even if you knew them.
/tg/ might be worth it if enough people knew tabletop and tcg references. Still a stretch.