The World said
Nope. In Soul Eater's case, the manga is the canon. And she's a girl in the manga, but a guy in the anime. Medusa literally calls Crona her daughter right before Crona kills her. Which doesn't happen in the anime (obviously).
I read the Soul Eater wiki article on Crona, and it states that while Crona's gender is ambiguous, Medusa always calls her "my child" and has never specified whether they were a son or daughter, including in the manga.