Yeah I was thinking about that. There are a lot of options.
There are a few at the top of my head
Coastal City: skyscrapers toppled over each other, the roads littered with idle cars trapped in gridlock, abandones subway stattions and trains inhabited by those unlucky enough to survive exposure to the raditions, most of them feral ghouls. Somewhere in the distance from the main city is the coast, an irradiated shore that is home to mutated sealife
Island: Maybe on Hawai'i or some unknown, but large, island that was once very populated and civilized.
Alaska: It doesn't snow too often, but on the rare occasion it does it isnt safe to go out. The snow that falls from the toxic clouds still carry the radition from the nuclear fallout. There are many forms of mutated wildlife
Or it could be taken someplace not in the USA, but im not too familar with other continents XD
They arent fleshed out by any means, just some thoughts. Throw some my way if you have any