Why must people be this cancerous?
Well That really depends. Are Eragon and Saphira in the Elder Scrolls universe? Does that make Saphira a Skyrim type dragon?
Lemme put it this way. If Eragon and Saphira are hamstrung by Skyrim rules Dragonborn wins. If they aren't Eragon and Sapphira win.
For starters Eragon is a mage. Under Brisingr rules a Mage is able to infiltrate their enemy's mind, seize control of their body and kill them with a single word. Ordinarily, wards and the threat of being countered by an enemy Mage helps to balance this power. The Dragonborn, bound by Skyrim's more traditional definition of magic, has no such defences against Brisingr's style of magic.
The fight would be over in seconds. Saphira wouldn't even have to do anything. Without the mental wards or ability to shield his mind from intrusion, which is unique the the Brisingr universe, the Dragonborn would be killed instantly by Eragon with a single word. Especially if this is post-Dragon Ritual Eragon, after he gets turned into a Half Elf. And even if the Dragonborn had the time to get out a Shout, like the one to control Dragons, that Shout only works because Skyrim dragon are bound by that universe's magic. In this case, Saphira is not a Skyrim dragon, therefore Shouts intended to defeat such dragons would have no effect on her.
I'm assuming everyone saying the DB would win hands down are either blinded by their love of Skyrim or basing the fight off of the Eragon and Saphira seen in the movie Eragon.
And don't even get me started on that... Bloody movie was an insult to the books.
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Which one has the best expanded universe backup?
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You joke, but it's possible. Kanye is a political outsider, a poor public speaker, and everyone has seen his wife naked. Par for the course.