One day, a journalist receives an e-mail from someone he doesn't know. It tells him that he should come ASAP to an asylum he'd done a paper on years earlier in Russia. The e-mail tells him that the patients are being used as test subjects by the doctors in an inhumane way. Although he isn't sure if it's true or not, he decides to return to the Asylum.
However, once inside, he becomes trapped in a world of terror as he realizes that the doctors and guards are dead, and the patients have become deformed and extremely unstable. He takes shelter in a room where he discovers a woman hiding under a desk. Although she is wearing patient clothing, she tells him she was a doctor in the asylum and locked up for disagreeing with the project... She's also the one who sent him the e-mail.
Unable to get downstairs the way he came up, the two decide to attempt survival together. He plans to record it all using a small shoulder-camera on his jacket, and she plans to figure out just what the project is meant to achieve.
They take up whatever they can find to use as weapons and begin a long journey through the massive asylum in search of food, water, and safety from the insanity that surrounds them.