How funny, I was just reading C.M. Kosemen's All Tomorrows and the odd evolution of mankind into the zone of what is in our view "body-horror" starting from exactly the same spot as this RP, 2250 AD.
I'm very interested in this! Feels like a great spot to develop characters who are passionate about their worldviews (A bit kinda Early 20th Century or 18th century's idealism)