I'll go ahead and tell everyone now, for the sake of allowing those interested to get into a certain mood about things with their characters, that Cerberus is actually going to be taking center stage in the overall story. While I will still be holding back specifics and the juicy plot twists until more appropriate times, I can say that they (or what is left of them following the Reaper War) will be the primary antagonists. The deal that Declan struck with Aria (which was omitted from my narration so far) revolves around this, so expect some fun main story missions.
Side missions will mostly consist of typical space pirate stuff, as well as your characters' loyal missions (of which I only have one submitted to me so far, so... *nudge nudge*).
Oh, and as a quick side note, since I realize some may not be totally familiar with military lingo: "RV" is common shorthand for "rendezvous".