Humanity is facing extinction in a world where technology is advancing rapidly, there is almost no use for them. Pushed to the outskirts of the newly developed city, they are forced to live in dirty slums where overpopulation is quickly taking its toll on those living there in the most deplorable conditions.
Vampirism surfaced decades ago, something that doctors predicted would wipe out the entire planet - and they were half right. This viral disease didn't kill humanity, however, it transformed it into more resilient creatures. They would outlive any human by hundreds of years unless they had been previously cybernetically enhanced, the only remaining humans were all enhanced, to varying degrees.
A certain vampire developed a synthetic blood formula, undoubtedly saving the vampire race entirely as their primary source of food was dwindling down to nothing. This technological discovery also helped humans indirectly, though they are still considered a delicacy to vampires and to those who have big enough balls to venture in the slums for a taste.
Crime in the city itself is non-existent, at least at first glance. But in the slums, small gangs run black markets for cybernetic enhancements which is the sort of most of the chaos there. The current state of affairs gave rise to a military organization, unknown to humans and vampires alike. They threaten all forms of life, forcing the enlistment of humans in order to get rid of vampires entirely.
Old enemies will have to work together in order to neutralize this threat. The awkward and certainly hostile state of the relationship between humans and vampires is sure to make this task very difficult, ye they have no other choice than to pull it together or they will see the destruction of their world as they know it.
If you have questions/suggestions let me know! I'm open to ideas and working with a CO-GM cause I feel this will require more than one mind to brainstorm.