So, the basic idea here is that Lucifer has been released from his cage. Michael has been up to some bullshit on earth, while trying to find and keep a temporary vessel. During said bullshit, he played "husband" to a woman that he had stolen her husband's body, by promising to protect her and her kids. What he didn't know, or didn't think about, was the fact that having sex with a human, even while undercover, makes scary things.
That scary thing is: The Nephilum.
So, now there's a baby coming, while the apocalypse is trying to come. Sam, Dean, and Cas are aware of the baby, but not quite aware of what it's capable of. The baby already knows of them. She has heard her mother speak of/to them, and she knows that they have considered killing her, but they don't feel like murderers.
(Like Jack 8 years later) Madison's mother has told her the world is a dangerous place, and she has heard of monsters from Sam and Dean, many times. So, she fully plans to alter her body, and become a young adult/older teenager as soon as her body is no longer protected by her mother's.
There's no way to know which fish is bigger - Lucifer or the Nephilum.
So, what would happen if in 2009 the brothers came across Michael's spawn, 8 years before they encountered Jack. How would it have changed the apocalypse?
That's the basic gist. I felt the need to post it here lol <3