The two plots that I have up at the moment are these:
The world to the south has been encased in war for centuries. The north is the refuge for those that do not wish to be a part of the fighting. There is a truce between sides, allowing this dichotomy to exist. A hospital in the north recently admitted a young girl with wounds of war, hardly over 16. As per the agreement, once a warrior crosses the territory, they are no longer required to serve and ultimately cut off. She is alone, only knows death and hatred, and will be released from the hospital without a home.
This can be twins, two brothers, or best friends, and explores the dynamics of them interacting and falling for the same woman. The setting can fit many different forms. I've attempted this story as a somewhat historical setting, fantasy, and as modern. It really depends on the types of characters you would like to play.
But I am open to trying something else as well.