I have a Mass Effect x Dead Space x Star Gate roleplay plot that I think you would definitely approve of. Logline: A large civilian spaceship is invaded by a mysterious entity. Captain Elizabeth, cold, hard and reckless, evacuates all aboard except herself, intending to go down with her ship. Her childhood friend and [head engineer, head doctor, pilot] won't let her, and together, with the help of their sassy AI, they have to survive.
Let me know if you're interested.