i'd say this is a meme, but Make it happen
derpicdn.net/img/2015/12/15/1045061/f…
I'm just going to admit I have no idea who those two characters on the right are. I do think Junko would be the hardest opponent if only because of her "reverse poker face."
It's boss.
i68.tinypic.com/o5z0cg.jpg
Chest isn't nearly hairy enough, haha!
Probably one of the better genderswaps I've seen for Junko. I don't think she's a character who really lends herself to having her gender changed. It's really hard for a guy to be everything Junko is and not come across as overly eccentric. Ibuki would be a character who is more easily genderswapped. Her accessories are more associated with punk than a particular gender, and her playful nature works well for either sex.
Not Danganronpa, but related
i65.tinypic.com/2myc0ib.jpg
I do this with almost all of my villains nowadays, and I can honestly say the players never hesitated to destroy them. Though most of that was over a D&D campaign where the players would burn down an orphanage if it meant getting 10 extra EXP.