Bugger. How many guards are there in the room at the moment? Enough for Fox and Patch to be able to take out with their athletics, or would it be better to have Owl try and talk them all out of it?
Casualties, for the enemies at least, shouldn't be a problem at this point if the building's gonna be blown in a minute as they'll all be killed anyway, especially if they're taken out in unarmed combat as their deaths would look like they were caused by the explosion even if their bodies survived.
I take it the guards did disarm Owl and Patch? They knew both of them were carrying weapons after all.