I believe we should be defining super and then addressing how the characters become such. In general, there are four main types of characters that are considered superheroes:
Nick Furies/Coulsons/Black Widows/Green Arrow/Hawkeye: Badasses that are highly trained, but have no other notable traits aside from maybe one key skill.
Batmans/Ironmans/Green Arrow (if you count his arrow arsenal)/Robins/Nightwings: Characters with a unique arsenal, item, etc. that doesn't make them biologically inhumam.
Captain America/Red Skull/Death Stroke/Hulk: Characters that have somehow been made biologically superior to regular humans.
Mutants/Gods/Etc.: Anything that's superior to or different than regular humans by any other means.
Now, my question is: what do you want in this roleplay, why and for what reasons? For instance, do we want to make it as open as the Marvel and DC Universe with mutants, aliens, Gods, etc., or do we want to simplify it down? Do we want to bend the superhero genre into more a magic realism genre by maybe implementing a whole world similar to Static Shock's big plot with Bangbabies being mutants, essentially, while a task force of characters highly trained and similar to Captain America and/or Deathstroke being sent to hunt them down? Maybe we could put a twist on it that the mutations continue, something like the X-Gene? We could eliminate the paranormal and supernatural all together from the RP, but still keep some fantastical and even "superpowered" aspects to it?
Or, do we want to go full blown celestial universe where this all plays into some plan and is eventually intervened by the ancient Greek Gods to stop the second Trojan War caused by the Apple of Discord that was actually the cause of the mutations, having characters paralleling the story of the Iliad with a 90's twist on it, including Diomedes, Achilles, Paras, Hellen, etc.?
Those are just two thought-out examples. I'm preferential to the first one myself, but that's because I feel that a strong, simple plot to expand on later is best than a complex one involving a huge array of characters with diverse backgrounds being stitched together.
We also only have one person's opinion on the era for the RP. I'm personally all for starting out in the Roaring Twenties, but that is just my preference. I love doing historical research and making feasible plots. If you see a common trend in this, it's that I'm personally for diluting the "super" part of super. That's just what I would like. Don't be afraid to completely contradict that. I didn't make what I would like right off the bat for a reason and I'm not sticking to my guns here; I'm all up for you guys leaning it in different directions. I'm just trying to guide it.
Also, Worm is long as Hell with no brief synopsis in sight. I'm all for research, but that would take a while.
The really interesting idea I have in mind is what if we had superhumans vs. mutants while the superhumans slowly mutate, realizing that the only difference between them and the mutants they're fighting/killing is that the mutants had a bigger dose and mutated faster. They would face the crisis of identity and loyalty, as well as the uncertainty of how they would end up as the mutants themselves haven't stopped mutating yet some do become unstable to a fatal degree. They could face mutants with the same ideals as both Xavier and Magneto, except that in this case, its more clearcut what caused the mutations. Again, tossing out what I find interesting, but also tossing out the structural ideas I'm looking for here.