I've read that, in the eyes of the Spirit of Vengeance, all men are sinful, so I believe so. Don't quote me on it. It also worked on Doctor Strange, but I wouldn't say the man is specifically guilt-free.
Also, he has broken buildings in his epic battles, leaving many homeless men, well, shelterless. B) [[Kidding! Or am I...?]]
Edit: A brief amount of research pulled up some things such as the Penance Stare effecting anyone with guilt, sins, and regrets, and making them feel that for eternity. Ghost Rider has also Penance Stare'd heroes, so I believe it'd work on Superman, yes.
This was a fun discussion.
Also, he has broken buildings in his epic battles, leaving many homeless men, well, shelterless. B) [[Kidding! Or am I...?]]
Edit: A brief amount of research pulled up some things such as the Penance Stare effecting anyone with guilt, sins, and regrets, and making them feel that for eternity. Ghost Rider has also Penance Stare'd heroes, so I believe it'd work on Superman, yes.
This was a fun discussion.