The Guilds of Cybertron forced upon him the occupation of miner where he performed demolition operations. He eventually joined in the gladiator arenas. During his time as a gladiator, he learned the value of life in killing others. In between matches he became an intellectual often debating the caste system with fellow manners. His bosses asked him to take a fall in several matches, he refused the insult. He slaughtered his bosses and took over Kaon & Slaughter City. He rebranded himself as Megatronous after the greatest Prime of the Thirteen. He began publically denouncing Guilds of Cybertron, in response Sentinel Zeta Prime sent two agents to thwart him, he was forced to kill them.
A victorious battle with the Insecticons resulted in him being redubbed to Megatron by the crowd. It was after this fight that he began exchanging ideas in intense but friendly philosophical discussions with Orion Pax. He encouraged Orion to learn self defense and to visit Kaon. At this point Megatron was ready to start calling his movement Decepticons. He was also sending followers to search for artifacts of the Primes; their discovery would prove their cause was just. He was forced to publically distance himself from his followers as they began taking extremist measures, bombing Cybertron. During a meeting with Orion, the High Council, and himself his true motivations came to light. He threatened to overthrow the High Council if they didn't name him the next Prime. He killed Halogen a member of the High Council when Orion won the favor of the High Council and was redubbed Optimus. He publically declared that Optimus was no longer his brother but would continue to do so in private. The civil war started that day.

The Deceptions would eventually gain control of eighty-five percent of the planet. He was initially merciful but as the war dragged on any who did not join was slaughtered. Eventually the discovery of Dark Energon led to a new tactic but that would prove disastrous due to insufficient amount. The discovery of the Plasma Energy Chamber eventually led to the poisoning of Cybertron's core with Dark Energon darkening the entire planet, causing more Dark Energon to be produced. After the core stopped producing Dark Energon, Megatron learned that Optimus had acquired the Matrix from the core.

As the Autobots attempted to flee Cybertron via the last space bridge, Megatron ordered Trypticon to fire upon their ships. As the Autobots attempted to shut down Iacon, Optimus and Metroplex team up to fight the Decepticons to buy time for the Ark, the fight ends with Megatron's death. Soundwave recovers his corpse, after rebuidling Megatron's body and an infusion of Dark Energon revives Megatron. After the complete invasion of Iacon he ordered Trypticon to transform into the Nemesis. Using his and Orion's old frequency he contacted Optimus Prime, warning that he would hound him through the stars and finally kill him for the Matrix. He explained they were still brothers, as they were bonded for life despite their enmity. The Nemesis & Ark fight as they approach the last Space Bridge, when the Space Bridge detonated they found themselves crash landing on a nothing dustball. The crash landing forced them into stasis lock.

Megatron wakes up on Earth.