Name: Bloodlust (Anti-Viral)
Unique/Common: Uncommon Weapon
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Link to item: darksouls3.wiki.fextralife.com/Bloodlust
Description of function: “Katana of the old Mound-maker. The Mound-maker piled sacrifices upon the altar, but became the final offering himself, leaving this katana as a gift for his dear family. Causes natural Dark Souls bleed build up, which causes organs to burst in massive damage once enough stacks have been acquired. Attacks need not strike flesh to build up this kind of bleed. “Bloodlust,” weapon skill. When the wielder of the blade plunges it into their own body, it stains the blade in blood. This increases its sharpness, causing wounds created by the weapon to be twice as bad and inflict twice as many bleed stacks.

Name: Mound-Maker
Unique/Common: Common Trinket
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Link to item: darksouls3.wiki.fextralife.com/Mound-…
Description of function: “A malformed vertebra found by the mad, with a queer symbol on its inside, proof of the shackles of the Gods. Equip to pledge oneself to the Mound-makers covenant. The mound-makers wish only to add to their mounds, becoming mad spirits whether summoned as co-operators or invaders. They are blithe to those around them, for in their minds, any kill might lead to another shackle.” While invading with a Red Eye Orb, the aura is pink and black rather than red and black. Anyone killed by the Red Eye Orb user results in a permanent teleport, for better or for worse.

@Burning Kitty

Name: Gravity Suit
Series: Metroid
Uncommon: Armor Artifact
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Description of Function: Provides a bit more protection than the Varia Suit. In addition, the Gravity Suit allows the wearer to traverse through water or otherwise flooded rooms completely unhindered. Finally, the Suit grants access to the Spider Ball, Grapple Beam, Thermal Visor, and Power Bombs.

Name: Phazon Suit
Series: Metroid
Rare: Armor Artifact
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Description of Function: Provides a further damage protection, including complete immunity to Phazon Radiation. In addition, the Phazon Suit grants access to the X-Ray Visor, Speed Booster, Shine Spark, Space Jump, and Screw Attack.

Name: Epona
Series: Legend of Zelda
Common: Mount Artifact
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Description of Function: Link's faithful steed. She can be summoned almost anywhere by playing Epona's Song, either on an instrument or by whistling.

Name: Navi
Series: Legend of Zelda
Rare: Companion Artifact
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Description of Function: Link's partner and an indispensable ally in his quest. Navi does not engage in combat, however she can perform many other useful functions. She can detect invisible paths, doors, or enemies and reveal them to her companion. Once per day, when the player would normally die, Navi can revive them back to partial health.

Name: Amulet of Kings
Series: Elder Scrolls
Rare: Power Artifact
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Description of Function: Heirloom of the Septim Dynasty, passed down from St. Alessia. When worn, the player gains the Dragon Blood, allowing them access to the Dragonborn's power to Shout. The Amulet can also be broken to temporarily transform the user into a Dragon form, an avatar of Akatosh. While this form is very powerful and capable of overcoming just about any enemy, taking this form does permanently destroy the artifact in the process.

Name: Keyblade
Series: Kingdom Hearts
Uncommon: Weapon/Utility Artifact
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Description of Function: A blade of Light resembling a key, said to represent the strength of its wielder's Heart. In battle it can be used like any sword weapon, though it does more effective damage against Dark-aligned foes, and in addition it can be called to its master's hands from virtually anywhere. Outside of battle, it can be used as a Utility capable of opening virtually any lock without fail.

Name: Mjolnir
Series: Marvel's Thor
Uncommon: Weapon Artifact
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Description of Function: "Whosoever holds this hammer, if he be worthy, shall wield the power of Thor!" True to Odin's word, the wielder assumes Thor's strength, armor, and combat prowess in addition to the power to summon lightning... for the duration of one hour. The hammer can be recalled to the hand after thrown, and in addition allows its holder to fly... or at least leap very long distances. The only drawback is that while Mjolnir is in use, all other Artifacts must remain unequipped. After its use, the hammer requires a three hour cooldown period before its power can called upon again.

Name: Gravity Suit
Series: Metroid
Uncommon: Armor Artifact
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Link to item: metroid.wikia.com/wiki/Gravity_Suit
Description of Function: Provides a bit more protection than the Varia Suit. In addition, the Gravity Suit allows the wearer to traverse through water or otherwise flooded rooms completely unhindered. Finally, the Suit grants access to the Spider Ball, Grapple Beam, Thermal Visor, and Power Bombs.

Name: Phazon Suit
Series: Metroid
Rare: Armor Artifact
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Link to item: metroid.wikia.com/wiki/Phazon_Suit
Description of Function: Provides a further damage protection, including complete immunity to Phazon Radiation. In addition, the Phazon Suit grants access to the X-Ray Visor, Speed Booster, Shine Spark, Space Jump, and the Screw Attack. Finally, the Suit can channel pure Phazon to enter Hyper Mode, converting the Arm Cannon's Power Beam into the Phazon Beam.

Name: Epona
Series: Legend of Zelda
Common: Mount Artifact
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Link to item: zelda.wikia.com/wiki/Epona
Description of Function: Link's faithful steed. She can be summoned almost anywhere by playing Epona's Song, either on an instrument or by whistling.

Name: Navi
Series: Legend of Zelda
Rare: Companion Artifact
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Link to item: zelda.wikia.com/wiki/Navi
Description of Function: Link's partner and an indispensable ally in his quest. Navi does not engage in combat, however she can perform many other useful functions. She can detect invisible paths, doors, or enemies and reveal them to her companion. Once per day, when the player would normally die, Navi can revive them back to partial health.

Name: Amulet of Kings
Series: Elder Scrolls
Rare: Power Artifact
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Link to item: elderscrolls.wikia.com/wiki/Amulet_of…
Description of Function: Heirloom of the Septim Dynasty, passed down from St. Alessia. When worn, the player gains the Dragon Blood, allowing them access to the Dragonborn's power to Shout. The Amulet can also be broken to temporarily transform the user into a Dragon form, an avatar of Akatosh for a scant few minutes. While this form is very powerful and capable of overcoming just about any enemy, taking this form does permanently destroy the artifact in the process.

Name: Keyblade
Series: Kingdom Hearts
Uncommon: Weapon/Utility Artifact
Image:

Link to item: khwiki.com/Keyblade
Description of Function: A blade of Light resembling a key, said to represent the strength of its wielder's Heart. In battle it can be used like any sword weapon, though it does more effective damage against Dark-aligned foes, and in addition it can be called to its master's hands from virtually anywhere. Outside of battle, it can be used as a Utility capable of opening virtually any lock without fail.

Name: Mjolnir
Series: Marvel's Thor
Uncommon: Weapon Artifact
Image:

Link to item: marvel.wikia.com/wiki/Mjolnir
Description of Function: "Whosoever holds this hammer, if he be worthy, shall wield the power of Thor!" True to Odin's word, the wielder assumes Thor's strength, armor, and combat prowess in addition to the power to summon lightning... for the duration of one hour. The hammer can be recalled to the hand after thrown, and in addition allows its holder to fly... or at least leap very long distances. The only drawback is that while Mjolnir is in use, all other Artifacts must remain unequipped. After its use, the hammer requires a three hour cooldown period before its power can called upon again.