ruronihs said
But you seem to forget the very theme of Gurren Lagann: "Do the impossible... See the invisible... Touch the untouchable... Break the unbreakable..." One Above All may be God, but that just makes him the most fitting kind prey. The Anti-Spiral tried phasing them out of reality, but Gurren Lagann literally broke the laws of the omniverse and came back on sheer willpower. Gurren Lagann embodies the idea of surpassing the limits imposed on us by apparent reality. One-Above-All seems content with omnipotence, so he has nowhere to go, and thus he would lose. He may be God, but Gurren Lagann is a God killer.
here is the flaw in your argument, the one above all is in control of ALL REALITIES! there is absolutely no where that Gurren Lagann could go that the one above all could not find and wipe out. the omniverse is every single reality and universe meaning that there is no other reality outside of it. also if your wiped from existence, there is no way of willing yourself back to reality, that is impossible unless someone or some power in existence pulled you back. Also I looked in to the Anti Spirals and it doesn't say anywhere that they are the creators of the omniverse, and there for are not on the same scale as the One Above All. at the most it is a stalemate, but in my opinion the one above all wins because he will simply know everything about the Anti Spirals and then wipe them of their powers when he gets the chance and then obliterate them from existence. Anti Monitor would be a better match for them then the One Above All. another thing, that anime sounds ridiculous and the main character is way too OP to the point where it sounds awful.
as i said before Larfleeze can own that anime single handily